A transmission medium is a system or substance that can mediate the propagation of signals for the purposes of telecommunication. Signals are typically imposed on a wave of some kind suitable for the chosen medium. For example, data can modulate sound, and a transmission medium for sounds may be air, but solids and liquids may also act as the transmission medium. Vacuum or air constitutes a good transmission medium for electromagnetic waves such as light and radio waves. While material substance is not required for electromagnetic waves to propagate, such waves are usually affected by the transmission media they pass through, for instance, by absorption or reflection or refraction at the interfaces between media. Technical devices can therefore be employed to transmit or guide waves. Thus, an optical fiber or a copper cable is used as transmission media.

Electromagnetic radiation can be transmitted through an optical medium, such as optical fiber, or through twisted pair wires, coaxial cable, or dielectric-slab waveguides. It may also pass through any physical material that is transparent to the specific wavelength, such as water, air, glass, or concrete. Sound is, by definition, the vibration of matter, so it requires a physical medium for transmission, as do other kinds of mechanical waves and heat energy. Historically, science incorporated various aether theories to explain the transmission medium. However, it is now known that electromagnetic waves do not require a physical transmission medium, and so can travel through the "vacuum" of free space. Regions of the insulative vacuum can become conductive for electrical conduction through the presence of free electrons, holes, or ions.